The fight takes place at the UK's biggest venue, Wembley Stadium, as the Brit defends his title for the third time.
What to expect
It promises to be an incredible boxing match. Anthony Joshua has transformed from a rising star into one of the biggest fighters on the planet. But this is his toughest test yet. After dispatching other heavyweights in just a few rounds, he's certainly got the biggest challenge of his career to face on Saturday night.
Wladimir Klitschko might have lost his belts to Tyson Fury at the end of 2015, but that was a freak result amongst an impressive career. The Ukrainian has suffered only 4 losses in 68 professional fights and is a former five time heavyweight champion.
He's eager to win back the title that Tyson Fury took from him and is relishing being the challenger this weekend.
The two fighters have very different styles. Klitschko is highly regarded as one of the sports elite technical boxers. He fights in a calculated manner, scoring points until he finds the right moment to strike. Most of his fights surpass the half way point and as he's got older, more of his fights are going to the judges scorecard.
Joshua on the other hand is all about speed and power. In his career to date, he's very much had the speed and height advantage over his opponents. Most of his fights are over within a few rounds and he's yet to go the distance in a professional bout.
That's what makes Saturday night so interesting. Bar Dillian Whyte, AJ has never looked troubled in the ring. But the experience and composure of Klitschko is something he has never faced. Some still doubt AJ until he proves himself against a high quality opponent, so all eyes are firmly on him this Saturday night.
What do the bookies think?
Usually, Joshua is nailed on favourite to win his fight. Most people are tipping him to come out on top this weekend, but the odds are much tighter. Sky Bet are pricing Joshua as the 2/5 favourite with Klitschko the slight underdog at 2/1.
It's a tough one to call. Klitschko is likely to be cautious in his approach and see if Joshua tires in the later rounds. So AJ will be hoping he can get the upper hand early on and shake the Ukrainians game plan. It's very rare to see the Ukrainian knocked out, so our prediction is the first time in Anthony Joshua's career, it's going to go to the judges scorecards. AJ to win on points!
As ever with the big box office bouts, there's a huge undercard with some very exciting fights. For the third major televised fight in a row, Katie Taylor will box on the undercard, this time against Nina Meinke. She is currently undefeated in her professional career and on Saturday has the chance to claim the WBA Intercontinental Lightweight Title.
Also fighting are former Olympic gold medallist Luke Campbell, who defends WBC Silver Lightweight title against Darleys Perez and 2016 Team GB fighter Josh Kelly, who makes his professional debut against Faheem Khan. Another of the 2016 Team GB squad, Lawrence Okolie, also continues his professional career with his third fight, this time against Russ Henshaw.
However, the big match-up pre-Joshua involves Scott Quigg. Quigg lost his Super Bantamweight Title to fellow Brit Carl Frampton in February 2016, but bounced back quickly to claim the WBA International Featherweight Title against Mexican Jose Cayetano. On Saturday he defends his title for the first time against Viorel Simion of Romania, who is also the WBF World Featherweight Champion.
Find a Boxing Class Near You
With such a mouthwatering lineup, it might be giving you the urge to try a boxing class yourself. Well that's where Martial Arts Near You can help! There are thousands of Martial Arts classes across the UK for you to choose from.
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